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KMID : 0380620200520050546
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Korean Journal of Food Science and Technology
2020 Volume.52 No. 5 p.546 ~ p.554
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Usage- and daily intake-based cytotoxicity study of frequently used natural food additives in South Korea
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Yu Jin
Kim Ye-Hyun
Choi Soo-Jin
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Abstract
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Natural food additives have recently attracted attention as alternatives to synthetic additives. However, little information is available regarding their potential toxicity. In this study, we evaluated ten different natural food additives that are widely used in commercial foods in South Korea based on their actual usage level and daily intake. The results showed that none of the tested natural additives exhibited cytotoxicity in terms of inhibition of cell proliferation/viability and lactate dehydrogenase leakage. Additionally, the tested natural food additives did not generate intracellular reactive oxygen species (ROS), whereas they significantly decreased intracellular ROS levels produced by hydrogen peroxide.
Moreover, none of the tested natural additives affected cell proliferation and viability in 2D and 3D intestinal epithelium models. Taken together, the ten natural food additives did not exhibit cytotoxicity in their actual usage levels. These findings can be used to further assess the toxicity of natural food additives.
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KEYWORD
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natural food additives, cytotoxicity, actual usage level, daily intake
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